Patents / Publicactions

Patents

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Inventors: Pérez Fernández R, Canal Martín A, Sánchez Barrena MJ, Mansilla Aparicio A
Title: ACYLHYDRAZONES AS SYNAPTIC FUNCTION MODULATORS
Application No: PCT/ES2019/070649
Owner: CSIC-Fundación Ramón y Cajal

Inventors: Pérez Fernández R, Canal Martín A, Sánchez Barrena MJ, Mansilla Aparicio A.
Title: ACYLHYDRAZONES AS SYNAPTIC FUNCTION MODULATORS
Application No: P201830933
Owner: CSIC-Fundación Ramón y Cajal

Inventors: Martínez A, Gil C, Campillo NE, Sánchez-Barrena MJ, Mansilla A, Ferrús, A.
Title: AMINOFENOTIAZINAS PARA LA MODULACIÓN DEL NÚMERO DE SINAPSIS
Application No: PCT/ES2016070649. WO2017051046A1 (extended to USA and Europe from 23/04/2018
Owner: CSIC


Publications

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TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
JM Godoy -Corchuelo, Z Ali, JM Brito Armas, AB Martins-Bach, I García-Toledo, LC Fernández-Beltrán, JI López-Carbonero, P Bascuñana, S Spring, I Jimenez-Coca, RA Muñoz de Bustillo Alfaro, MJ Sánchez-Barrena, RR Nair, BJ Nieman, JP Lerch, KL Miller, HP Ozdinler, EMC Fisher, TJ Cunningham, A Acevedo-Arozena, S Corrochano
Neurobiology of Disease (2024) 193:106437  (doi: 10.1016/j.nbd.2024.106437)

The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A
Daniel Muñoz-Reyes, Levi J McClelland, Sandra Arroyo-Urea, Sonia Sánchez-Yepes, Juan Sabín, Sara Pérez-Suárez, Margarita Menendez, Alicia Mansilla, Javier García-Nafría, Stephen Sprang, Maria José Sánchez-Barrena*
eLife (2023) 12:e86151  (doi: 10.7554/eLife.86151)  (see also this picture)
bioRxiv 2022.12.09.519724  (2022)   (doi: 10.1101/2022.12.09.519724)

The inhibition of NCS-1 binding to Ric8a rescues fragile X syndrome mice model phenotypes
Cogram P, Fernández-Beltrán LC, Casarejos MJ, Sánchez-Yepes S, Rodríguez-Martín E, García-Rubia A, Sánchez-Barrena MJ, Gil C, Martínez A, Mansilla A*
Frontiers in Neuroscience (2022) 16, 1007531  (doi: 10.3389/fnins.2022.1007531)

The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites
Juan L Benavente,  Dritan Siliqi,  Lourdes Infantes,  Laura Lagartera,  Alberto Mills,  Federico Gago,  Noemí Ruiz-López,  Miguel A Botella,  María J Sánchez-Barrena,  Armando Albert*
Life Science Alliance (2021) 4, e202101152  (doi: 10.26508/lsa.202101152)

Recognition and activation of the plant AKT1 potassium channel by the kinase CIPK23
Maria Jose Sanchez-Barrena, Antonio Chaves-Sanjuan, Natalia Raddatz, Imelda Mendoza, Alvaro Cortes, Federico Gago, Juana Maria Gonzalez-Rubio, Juan Luis Benavente, Francisco J. Quintero, Jose M. Pardo, Armando Albert*
Plant Physiology (2020) 182, 2143–2153  (doi:10.1104/pp.19.01084)

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
Andrea Canal-Martín, Javier Sastre, María José Sánchez-Barrena*, Angeles Canales, Sara Baldominos, Naiara Pascual, Loreto Martínez-González, Dolores Molero, Mª Encarnación Fernández-Valle, Elena Sáez, Patricia Blanco-Gabella, Elena Gómez-Rubio, Sonsoles Martín-Santamaría, Almudena Sáiz, Alicia Mansilla*, F. Javier Cañada, Jesús Jiménez-Barbero, Ana Martínez & Ruth Pérez-Fernández*
Nature Communications (2019) 10, Article number: 2798  (doi:10.1038/s41467-019-10627-w)

Deciphering the inhibition of the neuronal calcium sensor 1 and the guanine exchange factor Ric8a with a small phenothiazine molecule for the rational generation of therapeutic synapse function regulators
Roca C, Martínez-González L, Daniel-Mozo M, Sastre J, Infantes L, Mansilla A, Chaves-Sanjuán A, González-Rubio JM, Gil C, Cañada J,  Martínez A, Sánchez-Barrena MJ* and Campillo NE*
Journal of Medicinal Chemistry (2018)  Article ASAP  (doi:10.1021/acs.jmedchem.8b00088)

Structural Biology of Salt and Drought Tolerance in Plants
Sánchez-Barrena, María J; Martinez-Ripoll, Martín; and Albert, Armando*
In eLS (2018). John Wiley & Sons, Ltd: Chichester  (doi: 10.1002/9780470015902.a0027628)

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome
Alicia Mansilla, Antonio Chaves-Sanjuan, Nuria E. Campillo, Ourania Semelidou, Loreto Martínez-González, Lourdes Infantes, Juana María González-Rubio, Carmen Gil, Santiago Conde, Efthimio M. C. Skoulaki, Alberto Ferrús, Ana Martínez, María José Sánchez-Barrena*
Proceedings of the National Academy of Sciences, PNAS (2017) 114, E999–E1008  (doi:10.1073/pnas.1611089114)

Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling
Maira Diaz¹, Maria Jose Sanchez-Barrena¹, Juana Maria Gonzalez-Rubio, Lesia Rodriguez, Daniel Fernandez, Regina Antoni, Cristina Yunta, Borja Belda-Palazon, Miguel Gonzalez-Guzman, Marta Peirats-Llobet, Margarita Menendez, Jasminka Boskovic, Jose A. Marquez, Pedro L. Rodriguez, and Armando Albert*
Proceedings of the National Academy of Sciences, PNAS (2016) 113, E396-E405 (doi:10.1073/pnas.1512779113)

The bacteriocin AS-48 requires dimer dissociation followed by hydrophobic interactions with the membrane for antibacterial activity.
Cebrián R, Martínez-Bueno M, Valdivia E, Albert A, Maqueda M, Sánchez-Barrena MJ*
Journal of  Structural Biology (2015) 190, 162–172  (doi:10.1016/j.jsb.2015.03.006)

Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress
Antonio Chaves-Sanjuan, Maria Jose Sanchez-Barrena, Juana Maria Gonzalez-Rubio, Maria Moreno, Paula Ragel, Marta Jimenez, Jose M. Pardo, Martin Martinez-Ripoll, Francisco J. Quintero, and Armando Albert*
Proceedings of the National Academy of Sciences, PNAS (2014) 111, 4532-4541  (doi:10.1073/pnas.1407610111)

The guanine-exchange factor Ric8a binds the calcium sensor NCS-1 to regulate synapse number and probability of release
Jesús Romero-Pozuelo, Jeffrey S. Dason, Alicia Mansilla, Soledad Baños-Mateos, José L. Sardina, Antonio Chaves-Sanjuán, Jaime Jurado-Gómez, Elena Santana, Harold L. Atwood, Ángel Hernández-Hernández, María-José Sánchez-Barrena and Alberto Ferrús*
Journal of Cell Science (2014) 127, 4246-4259  (doi:10.1242/ ​jcs.152603)

Frq2 from Drosophila melanogaster: cloning, expression, purification, crystallization and preliminary X-ray analysis
Baños-Mateos S, Chaves-Sanjuán A, Mansilla A, Ferrús A, Sánchez-Barrena MJ*
Acta Crystallographica (2014) F70, 530-534   (doi:10.1107/S2053230X14005408)

Preliminary crystallographic analysis of the ankyrin-repeat domain of Arabidopsis thaliana AKT1: identification of the domain boundaries for protein crystallization
Chaves-Sanjuán A, Sánchez-Barrena MJ, González-Rubio JM, Albert A*
Acta Crystallographica (2014) F70, 509-512   (doi:10.1107/S2053230X14005093)

Evolutionary Adaptation of the Fly Pygo PHD Finger toward Recognizing Histone H3 Tail Methylated at Arginine 2
Thomas C.R. Miller, Juliusz Mieszczanek, María José Sánchez-Barrena, Trevor J. Rutherford, Marc Fiedlersend, Mariann Bienz*
Structure (2013) 21, 2208-2220  (doi:10.1016/j.str.2013.09.013)

Structural Biology of a Major Signaling Network that Regulates Plant Abiotic Stress: The CBL-CIPK Mediated Pathway
María José Sánchez-Barrena, Martín Martínez-Ripoll and Armando Albert*
International Journal of Molecular Sciences (2013) 14, 5734-5749  (doi:10.3390/ijms14035734)

Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis
Sánchez-Barrena, M.J.*, Vallis, Y., Clatworthy, M.R., Doherty, G.J., Veprintsev, D.B., Evans, P.R. and McMahon, H.T.*
PLoS One (2012) 7(12), e52401  (doi:10.1371/journal.pone.0052401)

Structural insights on the plant Salt-Overly-Sensitive 1 (SOS1) Na⁺/H⁺ antiporter
Rafael Núñez-Ramírez¹, María José Sánchez-Barrena*¹, Irene Villalta, Juan F. Vega, Jose M. Pardo, Francisco J. Quintero, Javier Martinez-Salazar and Armando Albert*
Journal of Molecular Biology (2012) 424, 283-294  (doi:10.1016/j.jmb.2012.09.015)

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex
Fiedler M¹, Sánchez-Barrena MJ¹, Nekrasov M, Mieszczanek J, Rybin V, Müller J, Evans P, Bienz M*
Molecular Cell (2008) 30(4), 507-518  (doi:10.1016/j.molcel.2008.03.011)

The complex between SOS3 and SOS2 regulatory domain from Arabidopsis thaliana: Cloning, expression, purification, crystallization and preliminary X-ray analysis
Sánchez-Barrena, M.J., Moreno-Pérez, S., Angulo, I., Martínez-Ripoll, M. and Albert, A.*
Acta Crystallographica (2007) F63, 568-570  (doi:10.1107/S174430910702533X)

The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3
María José Sánchez-Barrena, Hiroaki Fujii, Ivan Angulo, Martín Martínez-Ripoll, Jian-Kang Zhu and Armando Albert*
Molecular Cell (2007) 26, 427-435  (doi:10.1016/j.molcel.2007.04.013)

The structure of the Arabidopsis thaliana SOS3: molecular mechanism of sensing calcium for salt stress response
Sánchez-Barrena, M.J., Martínez-Ripoll, M., Zhu, J.K. and Albert, A.*
Journal of Molecular Biology (2005) 345, 1253-1264   (doi:10.1016/j.jmb.2004.11.025)

Peptide AS-48: prototype of a new class of cyclic bacteriocins
Maqueda M, Galvez A, Bueno MM, Sanchez-Barrena MJ, Gonzalez C, Albert A, Rico M, Valdivia E*
Current Protein and Peptide Science (2004) 5, 399-416   (doi:10.2174/1389203043379567)

SOS3 (salt overlay sensitive 3) from Arabidopsis thaliana: expression, purification, crystallization and preliminary X-ray analysis
Sánchez-Barrena, M.J., Martínez-Ripoll, M., Zhu, J.K. and Albert, A.*
Acta Crystallographica (2004) D60, 1272-1274   (doi:10.1107/S0907444904008728)

Structure of Bacteriocin AS-48: From Soluble State to Membrane Bound State
Sánchez-Barrena, M.J., Martinez-Ripoll, M., Gálvez, A., Valdivia, E., Maqueda, M., Cruz, V. and Albert, A.*
Journal of Molecular Biology (2003) 334, 541-549   (doi:10.1016/j.jmb.2003.09.060)

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