Publications  (first or co-first authorship underlined)
J. Inmaculada Pérez Dorado

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A
M. Jamshidiha, T. Layon-Hogg, C.L. Sutherell, G.B. Craven, M. Tersa, E. De Vita, D. Brustur, I. Pérez-Dorado, S. Hassan, R. Petracca, R.M. Morgan, M. Sanz-Hermández, J.C. Norman, Al. Armstrong, D.J. Mann, E. Cota, and E.W. Tate
RSC Medical Chemistry (2021)  (doi: 10.1039/D1MD00225B)

High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation

C. Dian, I. Pérez-Dorado, F. Rivière, T. Asensio, P. Legrand, M. Ritzefeld, M. Shen, E. Cota, T. Meinnel, E.W. Tate, C. Giglione
Nature Communications (2020) 28, 1132  (doi: 10.1038/s41467-020-14847-3)

Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a
M. Jamshidiha, I. Pérez-Dorado, J.W. Murray, E.W. Tate, E. Cota and R.J. Read
Acta Crystallographica (2019) D75, 342-353  (doi: 10.1107/S2059798318017825)

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus
A. Mousnier, A.S. Bell, B.D. Swieboda, J. Morales-Sanfrutos, I. Pérez-Dorado, J.A. Brannigan, J. Newman, M. Ritzefeld, J.A. Hutton, A. Guedan, A.S. Asfor, S.W. Robinson, I. Hopkins-Navratilova, A.J. Wilkinson, S.L. Johnston, R.J. Leatherbarrow, T.J. Tuthill, R. Solari, and E.W. Tate (2018). 
Nature Chemistry (2018) 10, 599-606  (doi: 10.1038/s41557-018-0039-2)

Unravelling the molecular basis of adhesion to the host via Als1, a major virulence factor from Candida albicans
I. Pérez-Dorado, S.M. Chee, L. Hale, R. Jones, N. Kichik, E. Tate, E. Cota
FEBS Journal (2016) 283 (Suppl. 1), 78-78

Crystal structure of the CupB6 adhesive tip from the chaperone-usher family of pili from Pseudomonas aeruginosa
M. Rasheed, J. Garnett, I. Pérez-Dorado, D. Mulh, A. Filloux, S. Matthews 
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics (2016) 1864, 1500-1505  (doi: 10.1016/j.bbapap.2016.07.010)

Structural insight into the TRIAP1-PRELI family of human mitochondrial phospholipid transfer complexes
X. Milara, J. Garnett, T. Tatsuta, F.A. Ali, H. Baldie, I. Pérez-Dorado, P. Simpson, E. Yague, T. Langer, and S. Matthews
EMBO Reports (2015) 16, 824-835  (doi: 10.15252/embr.201540229)

Structure and functions of choline binding proteins
S. Galán-Bartual, I. Pérez-Dorado, P. García and J.A. Hermoso
In Streptococcus Pneumoniae Molecular Mechanisms of Host-Pathogen Interactions (2015), Chap. 11, pp. 207-230. Jeremy Brown, Sven Hammerschmidt and Carlos Orihuela Eds., Elsevier. ISBN: 978-0-12-410530-0

VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface
G.G. Hesketh, I. Pérez-Dorado, L.P. Jackson, I.B. Schäffer, L. Wartosch, S.R. Gray, A.J. McCoy, O.B. Zeldin, E.F. Garman, M.E. Harbour, P.R. Evans, M.N.J. Seaman, J.P. Luzio, and D.J. Owen
Developmental Cell (2014) 9, 591-606   (doi: 10.1016/j.devcel.2014.04.010)

Structural and Phylogenetic Analysis of Rhodobacter capsulatus NifF: Uncovering General Features of Nitrogen-fixation (nif)-Flavodoxins
I. Pérez-Dorado and A. Bortolotti, N. Cortez, and J.A. Hermoso
International Journal of Molecular Sciences (2013) 14, 1152-1163  (doi:10.3390/ijms14011152)

Pneumococcal surface proteins: when the whole is greater than the sum of its parts
I. Pérez-Dorado, S. Galán-Bartual and J.A. Hermoso
Molecular Oral Microbiology (2012) 27, 221–245  (invited review) (doi:10.1111/j.2041-1014.2012.00655.x)

Insights into pneumococcal fratricide from crystal structure of the modular Killing Factor LytC
I. Pérez-Dorado, A. González, M. Morales, R. Sanles, W. Striker, W. Vollmer, S. Mobashery, J.L. García, M. Martínez-Ripoll, P. García and J.A. Hermoso
Nature Structural & Molecular Biology (2010) 17, 576-582 (doi:10.1038/nsmb.1817)

Crystallization of the pneumococcal autolysin LytC: in-house phasing using novel lanthanide complexes
I. Pérez-Dorado, R. Sanles, A. González, P. García, J.L. García, M. Martínez-Ripoll and J.A. Hermoso
Acta Crystallographica (2010) F66, 448-451 (doi:10.1107/S1744309110006081)

Structure and role in pathogenesis of pneumococcal cell-wall associated proteins
J.A. Hermoso, I. Pérez-Dorado and M. Martínez-Ripoll
Acta Crystallographica (2010) A66, s32-s32  (doi:

Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection
N. Cremades, A. Velázquez-Campoy, M. Martínez-Júlvez, J.L. Neira, I. Pérez-Dorado, J.A. Hermoso, P. Jiménez, A. Lanas, P.S. Hoffman and J. Sancho
ACS Chemical Biology (2009) 4, 928-938  (doi:

Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae
R. Molina, A, González, M. Stelter, I. Pérez-Dorado, R. Kahn, M. Morales, S. Campuzano, N.E. Campillo, S. Mobashery, J.L. García, P. García and J.A. Hermoso
EMBO Reports (2009) 10, 246-251  (doi: 10.1038/embor.2008.245)

Coenzyme binding and hydride transfer in Rhodobacter capsulatus ferredoxin/flavodoxin NADP(H) oxidoreductase
A. Bortoloti, I. Pérez-Dorado, G. Goñi, M. Medina, J.A. Hermoso, N, Carrillo and N. Cortez
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics (2009) 1794, 199-210  (doi: 10.1016/j.bbapap.2008.09.013)

The coenzyme binding site of bacterial ferredoxin/flavodoxin-NADP(H) reductases
I. Pérez-Dorado, J.A. Hermoso, G. Goñi, M. Medina, A. Bortolotti, N. Carrillo, and N. Cortez
in Flavins and Flavoproteins (2008). S. Frago, C. Gómez-Moreno and M. Medina Eds. 267-273.  ISBN: 978-84-7733-017-2

Structural Characterization of the Ferredoxin:NADP(H) Reductase and a Flavodoxin from Rhodobacter capsulatus by X-ray Crystallography.
I. Pérez-Dorado, J.A. Hermoso, A. Bortolotti and N. Cortez
In Flavins and Flavoproteins (2008). S. Frago, C. Gómez-Moreno and M. Medina Eds.  pp.261-266. ISBN: 978-84-7733-017-2

Crystallization of a flavodoxin involved in the nitrogen fixation in Rhodobacter capsulatus
I. Pérez-Dorado, A. Bortolotti, N. Cortez and J.A. Hermoso
Acta Crystallographica (2008) F64, 375-377  (doi: 10.1107/S1744309108008038)

Tuning of the FMN binding and oxido-reduction properties by neighboring side chains in Anabaena Flavodoxin
S. Frago, G. Goñi, B. Herguedas, J.R. Peregrina, A. Serrano, I. Pérez-Dorado, R. Molina, C. Gómez-Moreno, J.A. Hermoso, M. Martínez-Júlvez, S. G. Mayhew and M. Medina
Archives of Biochemistry and Biophysics (2007) 467, 206-217  (doi:10.1016/

Elucidation of the Molecular Recognition of Bacterial Cell Wall by Modular Pneumococcal Phage Endolysin Cpl-1
I. Pérez-Dorado, N. E. Campillo, B. Monterroso, D. Hesek, M. Lee, J. A. Páez, P. García, M. Martínez-Ripoll, J. L. García, S. Mobashery, M. Menéndez and J.A. Hermoso
Journal of Biological Chemistry (2007) 282, 24990-24999  (doi:10.1074/jbc.M704317200) 

Common conformational changes in flavodoxins induced by FMN and anion binding: The structure of Helicobacter pylori apoflavodoxin
M. Martínez-Júlvez, N. Cremades, M. Bueno, I. Pérez-Dorado, C. Maya, S. Cuesta-López, D. Prada, F. Falo, J.A. Hermoso and. J. Sancho
Proteins: Structure, Function and Bioinformatics (2007) 69, 581-594  (doi:10.1002/prot.21410)

C-terminal Tyrosine of Ferredoxin-NADP+ reductase in the hydride transfer processes with NAD(P)+/H
J. Tejero, I. Pérez-Dorado, C. Maya, M. Martínez-Júlvez, J. Sanz-Aparicio, C. Gómez-Moreno, J.A. Hermoso and M. Medina
Biochemistry (2005) 44, 13477-13490  (doi:10.1021/bi051278c) 

The Ferredoxin-NADP(H) Reductase from Rhodobacter capsulatus: Molecular Structure and Catalytic Mechanism
I. Nogués, I. Pérez-Dorado, S. Frago, C. Bittel, S. G. Mayhew, C. Gómez-Moreno, J. A. Hermoso, M. Medina, N. Cortez, and N. Carrillo
Biochemistry (2005) 44, 11730-11740  (doi:10.1021/bi0508183)

Structural Analysis of Interactions for Complex Formation between Ferredoxin-NADP+ Reductase and Its Protein Partners
T. Mayoral, M. Martinez-Julvez, I. Pérez-Dorado, J. Sanz-Aparicio, C. Gomez-Moreno, M. Medina, and J.A. Hermoso
Proteins: Structure, Function, and Bioinformatics (2005) 59, 592-602  (doi:10.1002/prot.20450)

Crystallization and preliminary X-ray diffraction analysis of ferredoxin-NADP(H) reductase from Rhodobacter capsulatus
I. Pérez-Dorado. C. Bittel, N. Cortez and J.A. Hermoso
Acta Crystallographica (2004) D60, 2332-2335  (doi:10.1107/S090744490402640X)