Publications
Armando Albert de la Cruz


2024

Inverse regulation of SOS1 and HKT1 protein localization and stability by SOS3/CBL4 in Arabidopsis thaliana
Francisco Gámez-Arjona, Hee Jin Park, Elena García, Rashid Aman, Irene Villalta, Natalia Raddatz, Raul Carranco, Akhtar Ali, Zahir Ali, Shah Zareen, Anna De Luca, Eduardo O. Leidi, Miguel Daniel-Mozo, Zheng-Yi Xu, Armando Albert, Woe-Yeon Kim, Jose M Pardo, Clara Sánchez-Rodriguez, Dae-Jin Yun, Francisco J. Quintero
Proceedings of the National Academy of Sciences (2024) 121(9) e2320657121   (doi: 10.1073/pnas.2320657121)




2023

Continuous development in macromolecular crystallography with CCP4
Martín Martinez-Ripoll and Armando Albert
Acta Crystallographica, Section D (2023) D79, 447-448  (doi: 10.1107/S205979832300445X)
(see also this link)

Structure-guided engineering of a receptor-agonist pair for inducible activation of the ABA adaptive response to drought
Jorge Lozano-Juste, Lourdes Infantes, Irene Garcia-Maquilon, Rafael Ruiz-Partida, Ebe Merilo, Juan Luis Benavente, Adrian Velazquez-Campoy, Alberto Coego, Mar Bono, Javier Forment, Begoña Pampín, Paolo Destito, Adrián Monteiro, Ramón Rodríguez, Jacobo Cruces, Pedro L. Rodriguez, and Armando Albert
Science Advances (2023) 9(10)   (doi: 10.1126/sciadv.ade9948)   (see also a video)




2022

El "Rockefeller" cumple 90 años en la vanguardia de la investigación científica
Albert, A., Martínez-Ripoll, M.
Anales de Química (2022) 118(4), 273-274  (link to the article)


Structure-Based Modulation of the Ligand Sensitivity of a Tomato Dimeric Abscisic Acid Receptor Through a Glu to Asp Mutation in the Latch Loop
Lourdes Infantes, Maria Rivera-Moreno, Miguel Daniel-Mozo, Juan Luis Benavente, Javier Ocaña-Cuesta, Alberto Coego, Jorge Lozano-Juste, Pedro L. Rodriguez, and Armando Albert
Frontiers in Plant Science (2022) 13: 884029  (doi: 10.3389/fpls.2022.884029)

PYL1- and PYL8-like ABA Receptors of Nicotiana benthamiana Play a Key Role in ABA Response in Seed and Vegetative Tissue
Gaston A. Pizzio, Cristian Mayordomo, Jorge Lozano-Juste, Victor Garcia-Carpintero, Marta Vazquez-Vilar, Sergio G. Nebauer, Kacper P. Kaminski, Nikolai V. Ivanov, Juan C. Estevez, Maria Rivera-Moreno, Armando Albert, Diego Orzaez and Pedro L. Rodriguez
Cells (2022) 11, 795   (doi: 10.3390/cells11050795)




2021

It takes two to tango: Unraveling a new post-translational modification involved in SnRK2.6 activation
Miguel Daniel-Mozo, Armando Albert
Molecular Plant (2021) 14, 1–3   (doi: 10.1016/j.molp.2021.08.003)

The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites
Juan L Benavente,  Dritan Siliqi,  Lourdes Infantes,  Laura Lagartera,  Alberto Mills,  Federico Gago,  Noemí Ruiz-López,  Miguel A Botella,  María J Sánchez-Barrena,  Armando Albert
Life Science Alliance (2021) published on line 18 August  (doi: 10.26508/lsa.202101152)


Synaptotagmins at the endoplasmic reticulum-plasma membrane contact sites maintain diacylglycerol homeostasis during abiotic stress
Ruiz-Lopez N, Pérez-Sancho J, Esteban Del Valle A, Haslam RP, Vanneste S, Catalá R, Perea-Resa C, Van Damme D, García-Hernández S, Albert A, Vallarino J, Lin J, Friml J, Macho AP, Salinas J, Rosado A, Napier JA, Amorim-Silva V, Botella MA.
Plant Cell (2021) 33, 2431–2453  (doi: 10.1093/plcell/koab122) 
 

Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs
Cercós P, Peraza DA, Benito-Bueno A, Socuéllamos PG, Aziz-Nignan A, Arrechaga-Estévez D, Beato E, Peña-Acevedo E, Albert A, González-Vera JA, Rodríguez Y, Martín-Martínez M, Valenzuela C, Gutiérrez-Rodríguez M.
International Journal of Molecular Sciences (2021) 22, 1419  (doi: 10.3390/ijms22031419) 

Identification of ABA Receptor Agonists Using a Multiplexed High-Throughput Chemical Screening
Jorge Lozano-Juste, Irene García-Maquilón, José Brea, Rocío Piña, Armando Albert, Pedro L. Rodriguez, María Isabel Loza
in Plant Chemical Genomics. Methods in Molecular Biology (2021) vol. 2213, Hicks G.R., Zhang C. (eds). Humana, New York, NY   (doi: 10.1007/978-1-0716-0954-5_9
 


2020


Recognition and activation of the plant AKT1 potassium channel by the kinase CIPK23
Maria Jose Sanchez-Barrena, Antonio Chaves-Sanjuan, Natalia Raddatz, Imelda Mendoza, Alvaro Cortes, Federico Gago, Juana Maria Gonzalez-Rubio, Juan Luis Benavente, Francisco J. Quintero, Jose M. Pardo, Armando Albert
Plant Physiology (2020) 182, 2143–2153  (
doi:10.1104/pp.19.01084)



2019

PYR/PYL/RCAR ABA receptors
Pedro L. Rodriguez, Jorge Lozano-Juste, Armando Albert
Advances in Botanical Research (2019) 92, 51-82  (doi:10.1016/bs.abr.2019.05.003)




2018

Structural Biology of Salt and Drought Tolerance in Plants
Sánchez-Barrena, María J; Martinez-Ripoll, Martín; and Albert, Armando
In eLS (2018). John Wiley & Sons, Ltd: Chichester  (doi: 10.1002/9780470015902.a0027628)




2017
 

The structure of ligand-bound intermediates of crop ABA receptors highlights the role of the PP2C as necessary ABA co-receptor
Moreno-Alvero M, Yunta C, Gonzalez-Guzman M, Lozano-Juste J, Benavente JL, Arbona V, Menéndez M, Martinez-Ripoll M, Infantes L, Gomez-Cadenas A, Rodriguez PL, Albert A
Molecular Plant (2017) 10, 1250–1253 (doi:10.1016/j.molp.2017.07.004)



2016
 
Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signaling
Maira Diaza, Maria Jose Sanchez-Barrena, Juana Maria Gonzalez-Rubio, Lesia Rodriguez, Daniel Fernandez, Regina Antoni, Cristina Yunta, Borja Belda-Palazon, Miguel Gonzalez-Guzman, Marta Peirats-Llobet, Margarita Menendez, Jasminka Boskovic, Jose A. Marquez, Pedro L. Rodriguez, and Armando Albert
Proceedings of the National Academy of Sciences, PNAS (2016) 113, E396-E405 (doi: 10.1073/pnas.1512779113)



2015

The bacteriocin AS-48 requires dimer dissociation followed by hydrophobic interactions with the membrane for antibacterial activity.
Cebrián R, Martínez-Bueno M, Valdivia E, Albert A, Maqueda M, Sánchez-Barrena MJ.
Journal of  Structural Biology (2015) 190, 162–172  (doi:10.1016/j.jsb.2015.03.006)

 
Molecular recognition of PTS-1 cargo proteins by Pex5p: implications for protein mistargeting in primary hyperoxaluria
Mesa-Torres N, Tomic N, Albert A, Salido E, Pey AL.
Biomolecules (2015) 5, 121-141  (doi:10.3390/biom5010121)




2014
 
C2-Domain Abscisic Acid-Related Proteins Mediate the Interaction of PYR/PYL/RCAR Abscisic Acid Receptors with the Plasma Membrane and Regulate Abscisic Acid Sensitivity in Arabidopsis
Lesia Rodriguez, Miguel Gonzalez-Guzman, Maira Diaz, Americo Rodrigues, Ana C. Izquierdo-Garcia, Marta Peirats-Llobet, Maria A. Fernandez, Regina Antoni, Daniel Fernandez, Jose A. Marquez, Jose M. Mulet, Armando Albert, and Pedro L. Rodriguez
The Plant Cell (2014) 26, 4802-4820  (doi:10.1105/tpc.114.129973)


Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress
Antonio Chaves-Sanjuan, Maria Jose Sanchez-Barrena, Juana Maria Gonzalez-Rubio, Maria Moreno, Paula Ragel, Marta Jimenez, Jose M. Pardo, Martin Martinez-Ripoll, Francisco J. Quintero, and Armando Albert
Proceedings of the National Academy of Sciences, PNAS (2014) 111, 4532-4541  (doi:10.1073/pnas.1407610111)

The consensus-based approach for gene/enzyme replacement therapies and crystallization strategies: the case of human alanine:glyoxylate aminotransferase
Mesa-Torres N, Yunta C, Fabelo-Rosa I, Gonzalez-Rubio JM, Sanchez-Ruiz JM, Salido E, Albert A, Pey AL
Biochemical Journal (2014) 462, 453-463  (doi:10.1042/BJ20140250)

Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance
Gonzalez-Guzman M, Rodriguez L, Lorenzo-Orts L, Pons C, Sarrion-Perdigones A, Fernandez MA, Peirats-Llobet M, Forment J, Moreno-Alvero M, Cutler SR, Albert A, Granell A, Rodriguez PL
Journal of  Experimental Botany (2014) 65, 4451-4464  (doi:10.1093/jxb/eru219)

Preliminary crystallographic analysis of the ankyrin-repeat domain of Arabidopsis thaliana AKT1: identification of the domain boundaries for protein crystallization
Chaves-Sanjuán A, Sánchez-Barrena MJ, González-Rubio JM, Albert A.
Acta Crystallographica (2014) F70, 509-512   (doi:10.1107/S2053230X14005093)

A través del cristal. Cómo la cristalografía ha cambiado la visión del mundo
Martín Martínez-Ripoll, Juan A. Hermoso y Armando Albert (coord.)
Editorial CSIC-Catarata (2014) ISBN: 978-84-00-09800-1.

Comunicación celular a escala atómica
Armando Albert
in A través del cristal. Cómo la cristalografía ha cambiado la visión del mundo (2014). (M. Martínez-Ripoll, J.A. Hermoso y Armando Albert, coord.), CSIC-Catarata, pp. 171-182, ISBN: 978-84-00-09800-1.

A través del cristal y más allá
Martín Martínez-Ripoll, Juan A. Hermoso y Armando Albert
in A través del cristal. Cómo la cristalografía ha cambiado la visión del mundo (2014). (M. Martínez-Ripoll, J.A. Hermoso y Armando Albert, coord.), CSIC-Catarata, pp. 183-188,  ISBN: 978-84-00-09800-1.

A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector
Riveron JM, Yunta C, Ibrahim SS, Djouaka R, Irving H, Menze BD, Ismail HM, Hemingway J, H. Ranson, A. Albert  and C.S. Wondji
Genome Biology (2014) 15, R27  (doi:10.1186/gb-2014-15-2-r27)



2013

The role of protein denaturation energetics and molecular chaperones in the aggregation and mistargeting of mutants causing primary hyperoxaluria type I
Mesa-Torres, N., Fabelo-Rosa, I., Riverol, D., Yunta, C., Albert, A., Salido, E., Pey, A.L.
PLoS ONE (2013) 8, e71963  (doi:10.1371/journal.pone.0071963)

The PYL4 A194T mutant uncovers a key role of PYR1-LIKE4/PROTEIN PHOSPHATASE 2CA interaction for abscisic acid signaling and plant drought resistance
Pizzio, G.A., Rodriguez, L., Antoni, R., González-Guzman, M., Yunta, C., Merilo, E., Kollist, H., Albert, A., Rodriguez, P.L.
Plant Physiology (2013) 163, 441-55 (doi: 10.1104/pp.113.224162)


Protein homeostasis defects of alanine-glyoxylate aminotransferase: new therapeutic strategies in primary hyperoxaluria type I
Pey, A.L., Albert, A., Salido, E.
Biomed Research International (2013) 2013:687658   (doi:10.1155/2013/687658)


Structural Biology of a Major Signaling Network that Regulates Plant Abiotic Stress: The CBL-CIPK Mediated Pathway
María José Sánchez-Barrena, Martín Martínez-Ripoll and Armando Albert
International Journal of Molecular Sciences (2013) 14, 5734-5749  (doi:10.3390/ijms14035734)




2012

Structural insights on the plant Salt-Overly-Sensitive 1 (SOS1) Na+/H+ antiporter
Rafael Núñez-Ramírez, María José Sánchez-Barrena, Irene Villalta, Juan F. Vega, Jose M. Pardo, Francisco J. Quintero, Javier Martinez-Salazar and Armando Albert
Journal of Molecular Biology (2012) 424, 283-294  (doi:10.1016/j.jmb.2012.09.015)

The Structural Domains of Pseudomonas aeruginosa Phosphorylcholine Phosphatase Cooperate in Substrate Hydrolysis: 3D Structure and Enzymatic Mechanism
Lourdes Infantes, Lisandro Horacio Otero, Paola Rita Beassoni, Cristhian Boetsch, Angela Teresita Lisa, Carlos Eduardo Domenech and Armando Albert
Journal of Molecular Biology (2012) 423, 503–514  (doi:10.1016/j.jmb.2012.07.024)

An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases
D. Bailey, E.P. Carpenter, A. Coker, S. Coker, J. Read, A.T. Jones, P. Erskine, C.F. Aguilar, M. Badasso, L. Toldo, F. Rippmann, J. Sanz-Aparicio, A. Albert, T.L. Blundell, N.B., Roberts, S.P. Wood and J.B. Cooper
Acta Crystallographica (2012) D68, 541-552  (doi: 10.1107/S0907444912004817)




2011
 
The structure of Arabidopsis Thaliana OST1 provides insights into the kinase regulation mechanism in response to osmotic stress
Cristina Yunta, Martín Martínez-Ripoll, Jian-Kang Zhu and Armando Albert
Journal of Molecular Biology (2011) 414, 135–144 (doi:10.1016/j.jmb.2011.09.041)

Crystallization and preliminary crystallographic analysis of a C2 protein from Arabidopsis thaliana
Maira Diaz, Lesia Rodriguez, Miguel Gonzalez-Guzman, Martin Martinez-Ripoll and Armando Albert
Acta Crystallographica (2011) F67, 1575–1578  (doi:10.1107/S1744309111040541)


SnRK2.6/OST1 from Arabidopsis thaliana: cloning, expression, purification, crystallization and preliminary X-ray analysis of K50N and D160A mutants
Cristina Yunta, Martin Martinez-Ripoll and Armando Albert
Acta Crystallographica (2011) F67, 364–368 (doi:10.1107/S1744309110053807)



2010

Crystallization and preliminary X-ray diffraction analysis of Pseudomonas aeruginosa phosphorylcholine phosphatase
L.H. Otero, P.R. Beassoni, C.E. Domenech, A.T. Lisa and A. Albert
Acta Crystallographica (2010) F66, 957-960 (doi:10.1107/S1744309110024061)

Structure of GroEL in Complex with an Early Folding Intermediate of Alanine Glyoxylate Aminotransferase
Armando Albert, Cristina Yunta, Rocío Arranz, Álvaro Peña, Eduardo Salido, José María Valpuesta and Jaime Martín-Benito 
Journal of Biological Chemistry (2010) 285, 6371-6376  (doi:10.1074/jbc.M109.062471)


 
2008
 
Crystallization and preliminary crystallographic analysis of merohedrally twinned crystals of MJ0729, a CBS-domain protein from Methanococcus jannaschii
P. Fernández-Millán, D. Kortazar, M. Lucas, M. L. Martínez-Chantar, E. Astigarraga, J. A. Fernández, O. Sabas, A. Albert, J. M. Mato and L. A. Martínez-Cruz
Acta Crystallographica (2008) F64, 605-609



2007

The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3
María José Sánchez-Barrena, Hiroaki Fujii, Ivan Angulo, Martín Martínez-Ripoll, Jian-Kang Zhu and Armando Albert
Molecular Cell (2007) 26, 427-435  [PDF-copy]

The complex between SOS3 and SOS2 regulatory domain from Arabidopsis thaliana: cloning, expression, purification, crystallization and preliminary X-ray analysis
Sánchez-Barrena, M.J., Moreno-Pérez,, S., Angulo, I., Martínez-Ripoll, M. and Albert, A.
Acta Crystallographica (2007) F63, 568-570



2006

Cell signaling and function organized by PB1 domain interactions
Moscat, J., Diaz-Meco, M.T., Albert, A. and Campuzano, S.
Molecular Cell (2006) 23, 631-640   [PDF-copy]

La Química de la vida a escala atómica
Hermoso, J.A., Sanz Aparicio, J. and Albert A.
Anales de Química (2006) 102(4), 15-22  [PDF-copy]

Biología a escala atómica
Albert, A.
La razón (2006) 2869, 29




2005

Structure of the functional domain of phi 29 replication organizer
Asensio, JL, Albert, A, Muñoz-Espín, D, González, C, Hermoso, JA, Villar, L, Jiménez-Barbero, J, Salas, M and Meijer, W
Journal of Biological Chemistry (2005) 280, 20730-20739

Structural basis for membrane anchorage of viral phi 29 DNA during replication
Albert A, Munoz-Espin D, Jimenez M, Asensio JL, Hermoso JA, Salas M, Meijer WJ.
Journal of Biological Chemistry (2005) 280, 42486-42489

The structure of the Arabidopsis thaliana SOS3: molecular mechanism of sensing calcium for salt stress response
Sánchez-Barrena, M.J., Martínez-Ripoll, M., Zhu, J.K. and Albert, A.
Journal of Molecular Biology (2005) 345, 1253-1264



2004

SOS3 (salt overlay sensitive 3) from Arabidopsis thaliana: expression, purification, crystallization and preliminary X-ray analysis
Sánchez-Barrena, M.J., Martínez-Ripoll, M., Zhu, J.K. and Albert, A.
Acta Crystallographica (2004) D60, 1272-1274

Structure of concanavalin A at pH 8: bound solvent and crystal contacts
Lopez-Jaramillo FJ, Gonzalez-Ramirez LA, Albert A, Santoyo-Gonzalez F, Vargas-Berenguel A, Otalora F
Acta Crystallographica (2004) D60, 1048-1046

Peptide AS-48: prototype of a new class of cyclic bacteriocins
Maqueda M, Galvez A, Bueno MM, Sanchez-Barrena MJ, Gonzalez C, Albert A, Rico M, Valdivia E.
Current Protein and Peptide Science (2004) 5, 399-416

Functional characterization of the yeast Ppz1 phosphatase inhibitory subunit Hal3: a mutagenesis study
Muñoz, I, Ruiz, A, Marquina, M, Barcelo, A, Albert, A, Ariño, J.
Journal of Biological Chemistry (2004) 279, 42619-42627



2003

Structure of bacteriocin AS-48: from soluble state to membrane bound state
Sanchez-Barrena, M.J., Martinez-Ripoll, M., Galvez, A., Valdivia, E., Maqueda, M., Cruz, V. and Albert A.
Journal of Molecular Biology (2003) 334, 541-549

Structural basis for selective recognition of pneumococcal cell wall by modular endolysin from phage Cp-1
Hermoso, J.A., Monterroso, B., Albert, A., Galan, B., Ahrazem, O., Garcia, P., Martinez-Ripoll, M., Garcia, J.L. and Menendez, M.
Structure (2003) 11, 1239-1249



2002

Crystallization and preliminary X-ray diffraction studies of the complete modular endolysin from Cp-1, a phage infecting Streptococcus pneumoniae
Monterroso, B., Albert, A., Martinez-Ripoll, M., Garcia, P., Garcia, J.L., Menéndez, M., Hermoso, J.A.
Acta Crystallographica (2002) D58, 1487-1489

TrwD, the hexameric traffic ATPase encoded by plasmid R388, induces membrane destabilization and hemifusion of lipid vesicles
Machon, C., Rivas, S., Albert, A., Goñi, F.M., de la Cruz, F.
Journal of Bacteriology (2002) 184, 1661-1668

Structural Enzymology of Li+ sensitive / Mg2+ dependent Phosphatases
Patel, S., Martinez-Ripoll, M., Blundell, T.L. and Albert, A.
Journal of  Molecular Biology (2002) 320, 1087-1094



2000

Structure of yeast Hal2p, a major target of lithium and sodium toxicity. Identification of a framework of interactions determining cation sensitivity
Albert, A., Yenush, L., Gil-Mascarell, R., Rodriguez, P.L., Patel, J., Martinez-Ripoll, M., Blundell, T.L. and Serrano, R.
Journal of Molecular Biology (2000) 295, 927-938

The X-ray structure of the FMN binding protein atHal3 provides the structural basis for the activity of a regulatory domain involved in signal transduction
Albert, A., Martínez Ripoll, M., Espinosa-Ruiz, A., Rodriguez, P.L., Culiañez-Macia, F. and Serrano, R.
Structure (2000) 8, 961-969



1999

Molecular study of the rat liver NADH: Cytochrome C oxidoreductase complex during development and aging
Torres-Mendoza, C.E., Albert A. and de la Cruz, M.J.
Molecular and Cellular Biochemistry (1999) 195, 133-142

A six-stranded double-psi beta barrel is shared by several protein superfamilies
Castillo, R.M., Mizuguchi, K., Dhanaraj, V., Albert, A., Blundell, T.L. and Murzin, A.G.
Structure (1999) 7, 227-236

Making the most of commercial sparse-matrix protein crystallization screening kits
Albert, A. and Martinez-Ripoll, M.
Journal of Applied Crystallography (1999) 32, 336-338



1998

Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self-processing
Albert, A., Dhanaraj, V., Genschel, U., Khan, G., Ramjee, M.K., Pulido, R., Sibanda, B.L., von Delft, F., Witty, M., Blundell, T.L., Smith, A.G. and Abell, C.
Nature Structural and Molecular Biology (1998) 5, 289-293  (doi:10.1038/nsb0498-289)

Protein Engineering Aspartic Proteinases: Site-Directed Mutagenesis, Biochemical Characterisation, and X-Ray Analysis of Chymosins with Substituted Single Amino Acid Substitutions and Loop Replacements

Albert, A., Blundell, T.L., Dhanaraj, V., Donate, L.E., Groves, M., Guruprasad, K., Nugent, P.G., Orprayoon, P., Pitts, J.E., Rufino, S., Srinivasan, N.,Williams, M. and Wilsher, J.
Adv. in Experimental Medicine and Biology (1998) 436, 169-177

The Aspartic Proteinases: An Historical Overview
Blundell, T.L., Guruprasad, K., Albert, A., Williams, M., Sibanda, B.L. and Dhanaraj, V.
Adv. in Experimental Medicine and Biology (1998) 436, 1-13



1997

Aspartic proteinases: From the first X-ray photos of pepsin crystals to hundreds of 3-D structures
Blundell, T.L., Guruprasad, K., Albert, A., Williams, M., Sibanda, B.L. and Dhanaraj, V.
Current Science (1997) 72, 483-489

Diethyl 2-Benzimidazol-1-ylsuccinate-Picric Acid (1/1). An Inclusion Molecular Complex
Zadarenko, P., Gil, M.S., Lopez, P., Ballesteros, P., Fonseca, I. and Albert, A.
Acta Crystallographica (1997) B53, 961-967

Tetrafluoro and dichloro derivatives of thiophene-fused DCNQI- and TCNQ-type acceptors: A synthetic, electrochemical and crystallographic study
Martin, N., deMiguel, P., Seoane, C., Albert, A. and Cano, F.H.
Journal of Materials Chemistry (1997) 7, 25-29

A study on the scope of the photochemical ring contraction of substituted 2-amino-3-cyano-4H-pyrans to cyclobutenes: crystal structure of 3-carbamoyl-3-cyano-1-ethoxycarbonyl-4-isopropyl-2-phenylcyclobutene
Armesto, D., Albert, A., Cano, F.H., Martin, N., Ramos, A., Rodriguez, M., Segura, J.L. and Seoane, C.
J. Chemical Society-Perkin Transactions I (1997) 22, 3401-3405



1996

New Synthetic Route to 1,2,4-Thiadiazolines and 1,3-Thiazolines via Thiadiazolopyridinium Salts
Martinez, A., Castro, A., Fonseca, I., Martinez-Ripoll, M., Cano, F.H. and Albert, A.
Heterocycles (1996) 43, 2657-2666

First asymmetric synthesis of 3-alkoxycarbonyl-2-amino-4-aryl-4H-naphtho[1,2-b]pyrans
Martin, N., MartinezGrau, A., Seoane, C., Marco, J.L., Albert, A. and Cano, F.H.
Journal of Heterocyclic Chemistry (1996) 33, 27-31

Protein engineering loops in aspartic proteinases: site-directed mutagenesis, biochemical characterization and X-ray analysis of chymosin with a replaced loop from rhizopuspepsin
Nugent, P.G., Albert, A., Orprayoon, P., Pitts, J.E., Blundell, T.L. and Dhanaraj, V.
Protein Engineering (1996) 9, 885-893

Synthesis, characterization, and theoretical study of sulfur-containing donor-acceptor DCNQI derivatives with photoinduced intramolecular electron transfer
Martin, N., Segura, J.L., Seoane, C., Orti, E., Viruela, P.M., Viruela, R., Albert, A., Cano, F.H., VidalGancedo, J., Rovira, C. and Veciana, J.
Journal of Organic Chemistry (1996) 61, 3041-3054

Synthesis and X-ray structure of 1,4-bis[4-(N,N-dimethylamino)- phenyl]buta-1,3-diyne: charge-transfer complex with acceptors
Rodriguez, J.G., Ramos, S., Martin-Villamil, R., Fonseca, I. and Albert, A.
J. Chemical Society, Perkin Transactions I (1996) 6, 541-543



1995

Interacciones aromáticas en empaquetamientos cristalinos
Albert, A. and Cano, F.H.
in Cristalografía, Serie: Nuevas Tendencias (1995). CSIC, Cano, F.H., Foces-Foces, C. y Martínez-Ripoll, M. (eds.)

Asymmetric Synthesis of 4-Alkyl-3,5-dialkoxycarbonyl-2,6-dimethyl-1,4-dihydropyridines
Martin, N., Martinez-Grau, A., Seoane, C., Marco, J.L., Albert, A. and Cano, F.H.
Tetrahedron: Asymmetry (1995) 6, 877-880

Tricyanovinylthiophenes as Novel Electron Acceptors for Organic Metals
de Lucas, A.I., Martin, N., de Miguel, P., Seoane, C., Albert, A. and Cano, F.H.
Journal of Materials Chemistry (1995) 5, 1141-1145



1994

Asymmetric Synthesis of 3-Alkoxycarbonyl-2-amino-5-cyano-4,6- diphenyl-4H-pyrans
Martin, N., Martinez-Grau, A., Seoane, C., Marco, J.L., Albert, A. and Cano, F.H.
Tetrahedron: Asymmetry (1994) 5, 1435-1438

Development of Methods for the Synthesis of Chiral, Highly Functionalized 2-Amino-4-Aryl-4H-Pyrans
Marco, J.L., Martin, N., Martinez-Grau, A., Seoane, C., Albert, A. and Cano, F.H.
Tetrahedron (1994) 50, 3509-3528

Single-Component Donor-Acceptor Organic Semiconductors Derived from TCNQ
Bando, P., Martin, N., Segura, J.L., Seoane, C., Orti, E., Viruela, P.M., Viruela, R., Albert, A. and Cano, F.H.
Journal of Organic Chemistry (1994) 59, 4618-4629



1993

Michael Addition of Malonitrile to alpha-Acetylcinnamamides
Martin, N., Martinez-Grau, A., Seoane, C., Marco, J.L., Albert, A. and Cano, F.H.
Liebigs Annalen der Chemie (1993) 801-804

A Novel Molecule for the Design of Organic Conductors: 2,5-bis (3-phenylpropyl)-7,7,8,8-Tetracyano-p-Quinodimethane
Martin, N., Segura, J.L., Seoane, C., Albert, A. and Cano, F.H.
Synthetic Metals (1993), 55-57, 1730-1734

7,7-Diphenylnorbornane: The first Cofacial Diphenylmethane Derivative
Garcia Martinez, A., Osio Barcina, J., Albert, A., Cano, F.H. and Subramanian, L.R.
Tetrahedron Letters (1993) 34, 6753-6756

Reactivity of Cinnamonitriles with 2-Cyano- and 2-Ethoxycarbonyl-acetohydrazides: A Novel One-step Preparation and Crystal Structure of 3-Oxopyrazolo[3,4-b]pyridines
Hadi, A., Martin, N., Mendez, C., Quintero, M., Seoane, C., Soto, J.L., Albert, A. and Cano, F.H.
J. Chemical Society, Perkin Transactions I (1993) 1743-1748

Michael Addition of Malonitrile to Chiral alpha-Acylacrylates
Marco, J.L., Martin, G., Martin, N., Martinez-Grau, A., Seoane, C., Albert, A., Cano, F.H.
Tetrahedron (1993) 49, 7133-7144

Novel Molecules for the Design of Organic Conductors. Synthesis of 7,7,8,8-Tetracyano-2,5-bis(3-phenylpropyl)-p-quinodimethane and N,N'-Dicyano-2,5-bis(3,-phenylpropyl)-p-quinodiimine and X-Ray Structure of the TCNQ Derivative
Martin, N., Segura, J.L., Seoane, C., Albert, A. and Cano, F.H.
J. Chemical Society, Perkin Transactions I (1993) 2363-2368



1992

Syntheses, electrochemical properties and crystal structure of tetracyano-p-quinodimethane (TCNQ) derivatives with pi-extended systems containing a sulfur atom
de la Cruz, P., Martin, N., Miguel, F., Seoane, C., Albert, A., Cano, F.H., Leverenz, A. and Hanack, M.
Synthetic Metals (1992) 48, 59-64

Synthesis and Crystal Structure of Piperidinium 2-Aryl [1,2,4] triazolo[1,5-a]pyridinides and their Neutralization to 2-Aryl [1,2,4]triazolo[1,5-a]pyridines
Hadi, A., Martin, N., Seoane, C., Soto, J.L., Albert, A. and Cano, F.H.
Journal of Heterocyclic Chemistry (1992) 29, 1229-1235

The First Asymmetric Synthesis of Polyfunctionalized 4H-Pyrans via Michael Addition of Malonitrile to 2-Acyl Acrylates
Gonzalez, R., Martin, N., Seoane, C., Marco, J.L., Albert, A. and Cano, F.H.
Tetrahedron Letters (1992) 33, 3809-3812

Novel pi-Extended Thiophene-Fused Electron Acceptors for Organic Metals
Cruz, P., Martin, N., Miguel, F., Seoane, C., Albert, A., Cano, F.H., Gonzalez, A. and Pingarron, J.M.
Journal of Organic Chemistry (1992) 57, 6192-6198

Synthesis, and Structural, Conformational and Pharmacological Studies of new Fentanyl Derivatives of the Norgranatane System
Fernandez, M.J., Huertas, R.M., Galvez, E., Orjales, A., Berisa, A., Labeaga, L., Gago, F., Fonseca, I., Sanz-Aparicio, J., Cano, F.H., Albert, A. and Fayos, J.
J. Chemical Society, Perkin Transactions II (1992) 687-695

Synthesis, Electrochemistry, and Crystal Structure of N,N'-dicyanoquinonediimine (DCNQI) Derivatives Containing Fused Benzene Rings
Martin, N., Navarro, J.A., Seoane, C., Albert, A. and Cano, F.H.
Journal of Organic Chemistry (1992) 57, 5726-5730

A Novel Bridgehead Azocine. The end of a controversy
Martin, N., Quinteiro, M., Seoane, C., Albert, A., Cano, F.H. and Abramovitch, R.A.
Tetrahedron (1992) 48, 1581-1584